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Which of the following general statement(s) about a G protein–coupled receptor is (are) TRUE? a. It contains 12 transmembrane domains. b. It is positioned with the N-terminus on the cytoplasmic face of the membrane. c. It is positioned with the C-terminus on the cytoplasmic face of the membrane. d. All of the above.

Answer :

Answer:

c. It is positioned with the C-terminus on the cytoplasmic face of the membrane.

Explanation:

G protein-coupled receptor or GPCR is a protein receptor. It is present only in eukaryotes. It is part of two main signal transduction pathways: phosphatidylinositol signal pathway and cAMP signal pathway. When a ligand binds to it, there is a confirmational change in it which leads to activation of G protein.

GPCR is an integral membrane protein receptor and has seven transmembrane (membrane spanning) domains. N terminus (NH2 part) of the receptor is extracellular and C terminus (COOH part) of the receptor is cytoplasmic. Hence option c is correct.  

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