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Large-scale cancer studies have found that the p53 gene is often mutated in tumor cells. In fact, the gene encoding the p53 protein is mutated in tumor cells more often than any of the other 20,000 human genes. Based on this information, why was the Bunz study important?

Answer :

henrifrank

Answer:

The study revealed the importance of p53 to the arrest of cell cycle, preventing DNA failure

Explanation:

The study from 1998 called "Requirement for p53 and p21 to sustain G2 arrest after DNA damage" shows that cells that could sustain G2 arrest, before mitosis, because of some DNA damage, were the cells with active p53 protein and in other cells gamma ray irradiated (provoking DNA damage), progression through the cell cycle was possible, which gives the idea of p53 be essential to guarantee that the DNA content in the nucleus is correct.

Bunz's study provided a deeper understanding of the role of the p53 gene in the cell cycle, which can be used to enhance the understanding of cancers pathways and lead to new therapeutic treatments.

Tumor suppressor genes are genes that in normal conditions repair errors in DNA, indicate to the cell when they must die (it is known as programmed cell death or apoptosis), slow down cell division, etc.

The p53 gene is a tumor suppressor gene expressed in the nucleus of normal cells, where P53 protein acts as a transcription factor.

This gene (p53) is involved in many signaling pathways such as cell senescence, cell cycle arrest, DNA repair, etc.

The work by F. Bunz (1998) provides useful information on how P53 protein regulates the expression of target genes and thus avoids the proliferation of cancer cells.

In conclusion, Bunz's study provided a deeper understanding of the role of the p53 gene in the cell cycle, which can be used to enhance the understanding of cancers pathways and lead to new therapeutic treatments.

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