Answer :
Integrins are trans-membrane proteins that can reversibly link the cytoskeleton of a cell to the extracellular matrix. When there is a transient period during which the cytoskeleton is not linked to the extracellular matrix, the result may be movement of cell through the extracellular matrix.
Explanation:
- The adherence of cell to the extracellular matrix is important to maintain the formatuon of tissue and cell-cell communication.
- Several factors contribute to adhere the cells to the matrix .Among them ,Integrins are one.
- Integrins are transmembrane proteins that establish a link between the extracellular matrix and the actin filaments of the cytoskeleton.
- The integrins play a major role as receptors during signal transduction.
- The activity of the integrins to attatch the cells to the matrix is regulated within the cell.
- When the integrins are regulated to lose their adhesive activity the cells become free to move through the extracellular matrix.