It would depend from person to person but
A) Losing your quality of life
Explanation:
Quality of life is never permanent for people. In the time of starting a new business one can expect to risk their quality of life but it can be seen as a risky investment to increase or enhance the quality of life one has eventually.
A way to see it would be about how quickly one can recover from the losses they incur. A loss of a home is quite permanent and is hard to recover, same with other options. one can fix their lifestyle with money and free time which they can have once the business goes well.