what makes amino acids different from each other?

last one The side groups are what make each amino acid different from the others. Of the 20 side groups used to make proteins, there are two main groups: polar and non-polar. These names refer to the way the side groups, sometimes called "R" groups, interact with the environment.
The amino-acids are different from each other due to their SIDE CHAINS.
In conclusion, amino-acids are different from each other due to their SIDE CHAINS.
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