2. FP1 and FP2 are 240 amino acids long. If only a single amino acid is different, what
percentage of amino acids are the same between the two proteins? Show your work.

2. FP1 and FP2 are 240 amino acids long. If only a single amino acid is different, what percentage of amino acids are the same between the two proteins? Show yo class=

Answer :

Amino acid sequences can be defined by a percentage of identity. This percentage indicates the number of identical residues between proteins or nucleic acids of a given alignment.

  • In this case, 240 aminoacids is the total length of the protein alignment (i.e. the alignment between FP1 and FP2 proteins)

  • In consequence, in this case, the percentage of identity is 99.58% because dissimilarity is equal to 1/240= 0.0041667%, thereby percentage of identity is equal to 100 - 0.0041667 = 0.995833%.

  • Nucleic acid (either DNA or RNA) sequences and amino acid sequences can be defined by the percentage of identity.

  • The percentage of identity can be used to discover proteins or protein regions (i.e., domains, linear motifs, etc) which exhibit homology, i.e., proteins/protein regions that are similar due to a common evolutionary origin.

In conclusion, the percentage of identity is determined by the number of identical nucleotides (DNA and RNA) or amino acid residues (proteins) over the total of nucleotides/amino acids in the local alignment.

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