Answer :
In the ovary, oocytes are held at metaphase II of meiosis until fertilization.This block released, when Progesterone activates c-Mos, which further phosphorylates maturation promotion factor (MPF).
Maturation promoting factor :
One of the major protein kinases that activates and acts as the master regulator for the M-phase transition is Cdk1/cyclin B, also known as maturation promoting factor or MPF. It phosphorylates and activates other downstream protein kinases and directly phosphorylates several structural proteins involved in cellular reorganization.
It also play a major role in chromatin condensation by phosphorylating condensins; a role in NEBD by phosphorylating lamins, nuclear pore complexes, and inner nuclear membrane proteins; a role in fragmentation of the Golgi apparatus by phosphorylating Golgi matrix proteins; and a role in spindle formation by phosphorylating centrosome-associated proteins and MAPs.
Learn more about metaphase here :
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