Answer :
Osteoblasts are the bone cells that produce new bone matrix. It is disease that heterogeneous disorder that effects skeletal tissues in which Type I collagen is the major protein component.
Osteogenesis imperfects is caused by faulty gene that affects the body's ability to produce collagen. The quality of collagen produced is either lower or poorer quality. If any parent have this disease then there is 50% chances that child also having the condition.
It is Type I through IV are caused by mutations in the COL 1A1 or COL 1A2 genes.The OI paradigm is that of collagen related bone dyspepsia with most dominate which causes by defects in Type I collagen by defects in gene whose products interact with collagen.
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