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The settlement founded in the early 1600s that was the most consequential for the future united states was

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It was "JamesTown", settlement in Virginia Colony.

About Jamestown it is famously said “Jamestown is where British Empire began”. Virginia Company of London was the founder of Jamestown or “James Fort” in 1607. Jamestown was also the capital of Virginia colony for more than eight decades. 

 

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